{"product_id":"akuammine-isolate","title":"Akuammine Isolate","description":"\u003ch2\u003ePure Akuammine Isolate\u003c\/h2\u003e\n\u003cp\u003eAkuammine Isolate is the purified primary alkaloid from \u003cem\u003ePicralima nitida\u003c\/em\u003e, the West African tree whose seeds are sold as akuamma. Whole akuamma seed and standard seed extracts carry akuammine alongside pseudo-akuammigine, akuammidine and a handful of related alkaloids. This is the single compound on its own, with the plant matter and the rest of the alkaloid profile removed.\u003c\/p\u003e\n\u003cp\u003eIt is a fine off-white to pale tan powder. Because it is an isolate rather than a seed powder, the working amounts are a fraction of what people are used to with akuamma. Weigh it on a milligram scale.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Is Akuammine?\u003c\/h2\u003e\n\u003cp\u003eAkuammine is an indole alkaloid and the most abundant alkaloid in akuamma seed, typically making up a little over half the total alkaloid content. In West Africa the seed has a long history of traditional use, and akuammine is the compound most often pointed to when people describe the seed's character.\u003c\/p\u003e\n\u003cp\u003eIn a full seed or seed extract, akuammine sits in a mix. Isolating it gives a standardized, repeatable starting point instead of the batch-to-batch swing you get with ground seed.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eChemistry\u003c\/h2\u003e\n\u003cp\u003eAkuammine is a monoterpenoid indole alkaloid with the molecular formula \u003cstrong\u003eC22H26N2O4\u003c\/strong\u003e and a molar mass near 382 g\/mol. It is structurally related to the other \u003cem\u003ePicralima\u003c\/em\u003e alkaloids, including pseudo-akuammigine, akuammidine, akuammicine and akuammiline.\u003c\/p\u003e\n\u003cp\u003eResearch on akuammine and the rest of the akuamma alkaloids is still limited and ongoing.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eEffects\u003c\/h2\u003e\n\u003cp\u003eIndividual response varies with serving size, body chemistry and prior experience.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA grounded, settled feeling\u003c\/li\u003e\n\u003cli\u003ePhysical ease\u003c\/li\u003e\n\u003cli\u003eMild relaxation without much sedation at lower amounts\u003c\/li\u003e\n\u003cli\u003eBitter taste, so most people capsule it or mix it into something\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eStart low. Because this is an isolated compound, small changes in serving size show up clearly.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003ch3\u003eFirst-Time Users\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eStart at \u003cstrong\u003e20 to 40 mg\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eWait at least \u003cstrong\u003e2 hours\u003c\/strong\u003e before considering more\u003c\/li\u003e\n\u003cli\u003eStep up slowly across future sessions, not within the same one\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eExperienced Users\u003c\/h3\u003e\n\u003cp\u003eMost settle somewhere in the \u003cstrong\u003e40 to 80 mg\u003c\/strong\u003e range depending on response. A milligram scale is not optional here. Eyeballing an isolate is how people get it wrong.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eOnset \u0026amp; Duration\u003c\/h2\u003e\n\u003cp\u003eOnset is commonly \u003cstrong\u003e30 to 60 minutes\u003c\/strong\u003e, and the experience usually runs \u003cstrong\u003e3 to 5 hours\u003c\/strong\u003e. Metabolism, serving size and whether it was taken with food all shift that.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eIs this the same as akuamma seed powder?\u003c\/h3\u003e\n\u003cp\u003eNo. Akuamma seed powder is ground whole seed and contains the full alkaloid profile plus plant material. This is the isolated akuammine alkaloid, which is far more concentrated by weight.\u003c\/p\u003e\n\u003ch3\u003eHow does it compare to your akuamma seed extract?\u003c\/h3\u003e\n\u003cp\u003eThe seed extract is a full-spectrum concentrate of everything in the seed. The isolate is one compound, standardized, so you get the same starting point every time.\u003c\/p\u003e\n\u003ch3\u003eDo I need a scale?\u003c\/h3\u003e\n\u003cp\u003eYes. Use a milligram scale accurate to 1 mg. Volumetric dosing in a liquid also works well at these amounts.\u003c\/p\u003e\n\u003ch3\u003eDo you sell this in bulk?\u003c\/h3\u003e\n\u003cp\u003eYes. The 50 gram and 100 gram sizes are priced for wholesale and formulation buyers. For anything above 100 grams, reach out and we will put a quote together.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eSafety Information\u003c\/h2\u003e\n\u003cp\u003eDo not combine with alcohol, sedatives or other depressants.\u003c\/p\u003e\n\u003cp\u003eAvoid driving or operating machinery until you know how this affects you.\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare provider before use if you are pregnant, nursing, taking prescription medications, or have a medical condition.\u003c\/p\u003e\n\u003cp\u003eKeep out of reach of children. Store in a cool, dry place away from direct sunlight.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eDisclaimer\u003c\/h2\u003e\n\u003cp\u003eThis product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the U.S. Food and Drug Administration (FDA).\u003c\/p\u003e\n\u003cp\u003eSold as a botanical research and reference material. Use responsibly.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAt a glance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePurified akuammine, the primary alkaloid of \u003cem\u003ePicralima nitida\u003c\/em\u003e seed\u003c\/li\u003e\n\u003cli\u003eFine off-white to pale tan powder\u003c\/li\u003e\n\u003cli\u003ePlant matter and the other seed alkaloids removed\u003c\/li\u003e\n\u003cli\u003eStandardized and repeatable, unlike ground seed\u003c\/li\u003e\n\u003cli\u003eNeeds a milligram scale, working amounts are small\u003c\/li\u003e\n\u003cli\u003eBulk 50 and 100 gram sizes for formulation buyers\u003c\/li\u003e\n\u003cli\u003eAdults 21 and over\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIsolate, extract or whole seed.\u003c\/strong\u003e Three formats of the same plant, and the difference is how much of the seed comes with the alkaloid:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhole seed\u003c\/strong\u003e: ground \u003cem\u003ePicralima nitida\u003c\/em\u003e, full alkaloid profile plus all the plant material. Bulky, very bitter, and it varies seed to seed. See \u003ca href=\"https:\/\/healingherbals.store\/products\/akuamma-seed-whole\"\u003ewhole akuamma seed\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeed extract\u003c\/strong\u003e: a full-spectrum concentrate of everything in the seed, with the bulk removed. See the \u003ca href=\"https:\/\/healingherbals.store\/products\/akuamma-seed-extract-resin\"\u003eseed extract resin\u003c\/a\u003e and the \u003ca href=\"https:\/\/healingherbals.store\/products\/akuamma-seed-extract-powder-akuammine\"\u003eseed extract powder\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsolate\u003c\/strong\u003e: this listing. One compound, nothing else, which is why it is the only one of the three you can measure the same way twice.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWorking with an isolate.\u003c\/strong\u003e A milligram scale accurate to 1 mg is the baseline, and volumetric measuring in a liquid works well at these amounts: dissolve a known weight into a known volume and measure by millilitre instead of by scoop. Weigh your capsules empty before filling if you are capping it, because the bitterness is severe enough that most people do.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage.\u003c\/strong\u003e Sealed, cool, dry and dark, away from direct sunlight, with a desiccant packet. A fine isolate powder cakes if it takes on moisture, and caked powder cannot be weighed accurately at these amounts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated products.\u003c\/strong\u003e Other single-compound isolates in the range include \u003ca href=\"https:\/\/healingherbals.store\/products\/kavain-isolate\"\u003eKavain Isolate\u003c\/a\u003e, \u003ca href=\"https:\/\/healingherbals.store\/products\/muscimol-isolate\"\u003eMuscimol Isolate\u003c\/a\u003e, \u003ca href=\"https:\/\/healingherbals.store\/products\/magnolia-bark-extract-honokiol-isolate-powder\"\u003eHonokiol Isolate\u003c\/a\u003e and \u003ca href=\"https:\/\/healingherbals.store\/products\/corydalis-l-thp-isolate-powder\"\u003eL-THP Isolate\u003c\/a\u003e. Everything is in \u003ca href=\"https:\/\/healingherbals.store\/collections\/botanical-extract\"\u003eBotanical Extracts\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon questions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhy does an isolate need a scale when seed powder does not?\u003c\/strong\u003e Seed powder is mostly plant material, so a small error is a small error. An isolate is the active compound alone, so the same spoon error is a large one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhat colour should it be?\u003c\/strong\u003e Off-white to pale tan. Both are normal for this compound.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCan I dissolve it instead of weighing every time?\u003c\/strong\u003e Yes. Volumetric measuring, a known weight into a known volume of liquid, is accurate and convenient at these amounts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIs there research on akuammine?\u003c\/strong\u003e Limited and ongoing. We do not make claims beyond the chemistry and the traditional record of the seed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo you quote above 100 grams?\u003c\/strong\u003e Yes, get in touch and we will put a quote together.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer.\u003c\/strong\u003e These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Sold as a botanical research and reference material. Akuamma is a traditional botanical, and traditional use does not establish that it will produce any particular result. Consult your healthcare provider before use if you are pregnant, nursing, taking prescription medications, or have a medical condition. Use at your own risk and keep out of reach of children. For adults 21 and over.\u003c\/p\u003e","brand":"Healing Herbals","offers":[{"title":"0.5 Gram","offer_id":51667704054006,"sku":null,"price":19.99,"currency_code":"USD","in_stock":true},{"title":"1 Gram","offer_id":51667704316150,"sku":null,"price":35.0,"currency_code":"USD","in_stock":true},{"title":"5 Grams","offer_id":51667704348918,"sku":null,"price":160.0,"currency_code":"USD","in_stock":true},{"title":"10 Grams","offer_id":51667704381686,"sku":null,"price":290.0,"currency_code":"USD","in_stock":true},{"title":"50 Grams","offer_id":51667704414454,"sku":null,"price":1250.0,"currency_code":"USD","in_stock":true},{"title":"100 Grams","offer_id":51667704447222,"sku":null,"price":2300.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/healingherbals.store\/products\/akuammine-isolate","provider":"Healing Herbals ","version":"1.0","type":"link"}