Corydalis Extract – L-Tetrahydropalmatine (L-THP) Isolate Powder

TL;DR: A concentrated L-Tetrahydropalmatine (L-THP) isolate from Corydalis yanhusuo root, HPLC lab-tested, in 1g, 5g and 10g sizes. It is a potent alkaloid for experienced adults who own a milligram scale and are prepared to start with a very small serving.

Corydalis Extract, L-THP Isolate Powder is a single alkaloid drawn from a root that Chinese herbalists have relied on for centuries. It is a concentrated L-Tetrahydropalmatine (L-THP) isolate, the primary active alkaloid found in Corydalis yanhusuo (Yan Hu Suo), one of the 50 fundamental herbs in traditional Chinese herbology. L-THP has the chemical formula C21H25NO4 and a molecular weight of 355.43 g/mol.

At a glance

• Form: isolate powder
• Source: root (tuber) of Corydalis yanhusuo
• Compound: L-Tetrahydropalmatine (L-THP), a berberine-type alkaloid, HPLC lab-tested for purity
• Traditional use: Yan Hu Suo has been decocted and included in classical formulas for hundreds of years
• Sizes: 1g, 5g, 10g
• Adults 21 and over

The plant

Corydalis yanhusuo is a small flowering plant in the poppy family, grown mainly in Zhejiang province. Among its many alkaloids, L-tetrahydropalmatine is the one most often singled out. This product isolates that compound and confirms it by HPLC, so you are working with one identified molecule, not the whole root.

Traditional use

Yan Hu Suo appears in Chinese materia medica texts dating back roughly a thousand years. The tuber was usually decocted or vinegar-processed before use, and was rarely used alone. It was combined with other herbs in formulas tailored to the person.

How to use it (read this first)

Best for: evening use. This is a potent alkaloid. Start low. Begin with a small serving in the evening and assess tolerance before increasing. A milligram scale is essential at this concentration. Never measure by eye or with a kitchen spoon. Some customers pre-fill capsules so each serving is consistent. Do not take it before driving or operating machinery, and do not use it every day without a break.

What to expect

The powder is bitter, which is typical of berberine-type alkaloids. Customers describe a heavy, quiet, wind-down feeling. Drowsiness is common, so plan to stay in.

How it compares

L-THP is far more concentrated than any whole-herb evening product we sell. If you want something gentler, look at our night-time botanicals.

Storage

Keep the container tightly closed in a cool, dry, dark spot. The powder is fine and can drift, so open it away from fans and moving air. Label it clearly and keep it well out of reach of children and pets.

Common questions

What does "L" in L-THP mean?
Tetrahydropalmatine exists in two mirror-image forms. The L form (also written as levo or (-)-THP) is the one that occurs naturally in Corydalis and is what this isolate contains.

How does this differ from whole corydalis root powder?
Whole root contains L-THP alongside dozens of other alkaloids and plant fiber. This isolate removes all of that and delivers the single compound, which is why the pack sizes are small.

Can I take it with medication?
Talk to your healthcare provider first if you take any medication or have a liver or heart condition.

FDA Disclaimer: This product is not intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA. For adult use only. Do not combine with alcohol, sedatives, or other CNS depressants. Not for use if pregnant or nursing. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

For adults 21 and over only.